Resistance to which antibiotic class is a growing concern in treating infections?

Resistance to fluoroquinolones is indeed a growing concern in the treatment of infections. Fluoroquinolones, which include commonly used antibiotics such as ciprofloxacin and levofloxacin, are known for their broad-spectrum activity against various gram-negative and some gram-positive bacteria. Over time, however, the emergence of resistance mechanisms, such as mutations in DNA gyrase and topoisomerase IV, has significantly compromised their effectiveness.

The rise of multi-drug-resistant strains, particularly among common pathogens such as Escherichia coli and Klebsiella pneumoniae, has made fluoroquinolone resistance particularly problematic. These resistant strains can lead to treatment failures and limit the options available for managing serious infections, necessitating the need for alternative treatments or approaches.

Monitoring of resistance patterns and prudent prescribing practices have become essential to mitigate this issue, as well as efforts to promote the appropriate use of fluoroquinolones when they are truly indicated.