What is the drug of choice to treat urethritis caused by Neisseria?

Ceftriaxone is the drug of choice for treating urethritis caused by Neisseria gonorrhoeae, particularly when gonococcal infections are suspected. This is because ceftriaxone is a broad-spectrum cephalosporin antibiotic that is effective against Neisseria species. In cases of suspected gonorrhea, ceftriaxone is often recommended in combination with another antibiotic, such as azithromycin, to cover for potential co-infection with Chlamydia trachomatis.

Doxycycline is typically used for bacterial infections caused by a variety of organisms, but it is not the primary treatment for gonococcal urethritis. Metronidazole is mainly effective against anaerobic bacteria and certain protozoa, making it suitable for different types of infections, but not for those caused by Neisseria. Azithromycin can be used for Chlamydia infections and is often part of combination therapy for gonorrhea, but it is not the first-line treatment for uncomplicated Neisseria infections on its own. Therefore, ceftriaxone stands out as the most appropriate choice for targeting Neisseria gonorrhoeae directly in cases of urethritis.