What is the optimal therapy for a healthcare worker with a positive PPD?

The optimal therapy for a healthcare worker with a positive PPD (Purified Protein Derivative) test is isoniazid (INH). A positive PPD test indicates that the individual has been exposed to the tuberculosis (TB) bacteria, which could signify latent TB infection. In such cases, it is crucial to initiate treatment to prevent the progression to active TB disease.

Isoniazid is the first-line medication used for this purpose because it effectively kills the dormant bacteria and reduces the risk of developing active tuberculosis. The treatment usually lasts for about 6 to 9 months, depending on individual patient factors and local guidelines.

Other options mentioned do not serve the purpose of treating latent TB. Clindamycin, for example, is an antibiotic that is more effective against certain types of bacterial infections but is not indicated for the treatment of TB. Doxycycline, another antibiotic, is primarily used for various infections but does not have a role in latent TB management. ELISA, or enzyme-linked immunosorbent assay, is a diagnostic test and not a treatment for latent TB infection.

In summary, isoniazid's effectiveness in targeting and eliminating dormant TB bacteria makes it the recommended choice for a healthcare worker with a positive PPD test