Which antibiotic class is associated with causing ruptured achilles tendon?

The association between fluoroquinolones and the risk of ruptured Achilles tendon is well documented in clinical studies. Fluoroquinolones, such as ciprofloxacin and levofloxacin, have been shown to disrupt collagen synthesis and thus increase the risk of tendon injuries, particularly in individuals over 60 years old, those who are taking corticosteroids, and those with underlying health conditions such as renal insufficiency.

The mechanism behind this tendon damage is linked to the way fluoroquinolones interact with connective tissue, leading to increased oxidative stress and ultimately resulting in tendon degeneration. Patients on fluoroquinolones are often advised to be cautious and monitor for symptoms of tendon pain, swelling, or rupture.

In contrast, other antibiotic classes like beta-lactams, aminoglycosides, and tetracyclines do not have this same association with tendon rupture. For instance, beta-lactams are primarily effective against bacterial cell wall synthesis and do not generally have effects on tendon integrity, while aminoglycosides have a different mechanism involving protein synthesis inhibition, and tetracyclines are mostly known for their ability to inhibit bacterial protein synthesis as well, without the same tendon-related risks.