Which of the following symptoms is NOT typically associated with a herpes simplex virus infection?

The symptom that is not typically associated with a herpes simplex virus infection is the presence of scrapable oral plaques. Herpes simplex virus (HSV), particularly type 1, is known for causing painful vesicular lesions, often around the mouth (cold sores) or genitals, and these lesions can manifest as grouped vesicles. Additionally, individuals may experience systemic symptoms such as a low-grade fever during initial outbreaks, as well as localized sensations like tingling and burning around the area where lesions will develop.

In contrast, scrapable oral plaques are more characteristic of other conditions, such as oral thrush, which is caused by Candida species, or other infections. These plaques can be scraped off, revealing a red, inflamed mucosa underneath, which is distinctly different from the herpes simplex lesions that do not form removable plaques. This distinction in symptomatology is key in differentiating between conditions associated with oral lesions.