Which organism is primarily responsible for Lyme disease?

The organism primarily responsible for Lyme disease is Borrelia burgdorferi. This spirochete bacterium is transmitted to humans through the bite of infected black-legged ticks (commonly known as deer ticks). Lyme disease is characterized by a distinctive rash called erythema migrans, flu-like symptoms, and can lead to serious long-term complications if untreated, including neurological and cardiac issues.

The other organisms listed have different associations: Escherichia coli is mostly known for causing gastrointestinal infections, Staphylococcus aureus is associated with skin infections and more severe conditions like pneumonia or sepsis, and Salmonella enterica is typically linked to food poisoning. Each of these organisms plays a significant role in different infectious disease contexts, but none are responsible for Lyme disease.