Why are fluoroquinolones contraindicated in children?

Fluoroquinolones are contraindicated in children primarily because they can cause cartilage development problems. This class of antibiotics has been shown to adversely affect the growing cartilage in developing animals, leading to concerns about potential long-term joint and bone issues in pediatric patients. Studies have indicated that fluoroquinolones can interfere with the normal maturation of cartilage, which is especially critical during periods of rapid growth in children.

While other serious side effects may be associated with fluoroquinolones, such as effects on the kidneys or the nervous system, these issues are not specific contraindications in the pediatric population. The risk of compromising joint health and promoting musculoskeletal disorders is a significant concern that drives the recommendation against using fluoroquinolones in children unless no alternative therapies are available.